ED 3-in-1 Pill
Two PDE5 inhibitors again, and a vitamin counted as the third ingredient.
An unapproved combination, but each component sits inside its own approved dosing envelope. The pairing lacks evidence; the individual doses are not the problem.
- Price
- From $1.63 / use
- Verdict
- Proceed carefully
- Sourcing
- Not verified at source
- Last checked
- 1 August 2026
Read this first
We are a competitor of the companies reviewed on this page. That is a conflict of interest and you should read everything here with it in mind. What we can offer against it: every factual claim is drawn from the company's own published material and linked, every clinical criticism applies equally to us where it applies, and we take no affiliate commission or referral fee from anyone named here — including from the retail pharmacies whose generics we rate most highly.
A compounded chewable mint pairing sildenafil and tadalafil with vitamin B12 — the cheapest per dose on this page. The third of the three is the one worth thinking about.
Not verified at source
Hims blocks automated access to its own pages, including its support documentation, so unlike every other entry here this one was not read at source. The details below are drawn from third-party reporting and search indexing of Hims' own published material, corroborated across more than one source. Doses of the two PDE5 inhibitors in this specific product could not be confirmed and are deliberately not stated. Treat this entry as less reliable than the others on this page, and verify against Hims directly before acting on it.
Reported specifications
- Reported composition
- Sildenafil, tadalafil and vitamin B12 in a compounded chewable mint
- Doses
- Not confirmed — we could not verify the strength of either PDE5 inhibitor
- FDA status
- Compounded. Hims' published material states that compounded drug products are not FDA-approved and that the FDA does not evaluate them for safety, effectiveness or quality.
- Wider product line
- Hims' compounded oral tablets are reported to contain one or more of sildenafil, tadalafil, vardenafil, fluoxetine, rosuvastatin, atorvastatin, vitamin B6, vitamin B12, L-arginine or zinc, depending on the individual prescription
- Consultation
- Online, asynchronous; no labs or examination described
Our assessment
The core of this is the same construction as Ro Sparks and Rocket Rise: two PDE5 inhibitors, same class, same enzyme, same additive effect on blood pressure, in a compounded product with no approval and no trial evidence for the pairing. Everything said about that above applies here without modification.
What is different is the third ingredient, and it is worth being precise about it. Vitamin B12 has no established role in treating erectile dysfunction in a man whose B12 is normal. If a man is genuinely deficient, that is a finding worth investigating on its own terms — it can point to diet, to malabsorption, to metformin use — and the answer to it is not a pinch of it folded into a mint. Counting a vitamin as one of the three in a 3-in-1 is a marketing decision rather than a pharmacological one.
We could not verify the doses, and that gap matters more than it might sound. The whole basis on which we assessed the other combination products was comparing their published strengths against approved ceilings. Without those numbers there is no way to tell whether this sits in the restrained end of the category or the aggressive end.
The wider product line is the part that would give us most pause in a consulting room. Hims' compounded tablets are reported to be personalised from a menu that includes fluoxetine and a statin. Those are not incidental additions. Fluoxetine is an SSRI with a notably long half-life, real discontinuation effects, and — relevant here specifically — inhibition of the liver enzyme that clears both sildenafil and tadalafil, which makes it an interaction question inside a combination tablet rather than a neutral extra. A statin is prescribed on the basis of cardiovascular risk assessment and monitored with blood tests, neither of which a questionnaire performs.
In fairness, the reported per-use price is the lowest of anything on this page, and there is a coherent argument behind bundling a statin with an ED treatment: erectile dysfunction genuinely is a cardiovascular warning sign, and we say so at length elsewhere on this site. The disagreement is not about whether such a man may need a statin. It is about whether a questionnaire is the right place to decide that.
Reasonable for
- Men already assessed and screened who want the lowest per-dose price in this category
- Men who will ask exactly which actives and what doses their specific prescription contains, and check the answer
Not for
- Anyone taking nitrates in any form, including recreational 'poppers'
- Men on an SSRI, or on any medication that interacts with one, if a formulation containing fluoxetine is offered
- Men already taking a statin, or who have never had lipids checked, if a statin-containing formulation is offered
- Men who would accept a personalised formulation without being told what is in it
- Men who have not had a blood pressure reading or blood work recently
Important
The information on this website is provided for general education and does not constitute medical advice, diagnosis, or treatment. Erectile dysfunction can be the first sign of cardiovascular disease, diabetes, or hormonal disorders. Always consult a licensed physician about your individual circumstances, and never start, stop, or change a prescription based on what you read here.
If you want the other thing
A diagnosis, rather than a subscription.
If you have already been assessed and just need a refill, this may serve you well. If nobody has taken your blood pressure in years, that is the appointment to make.